Ontology highlight
ABSTRACT:
SUBMITTER: Abu-Zaied MA
PROVIDER: S-EPMC7439276 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Abu-Zaied Mamdouh A MA Mahmoud Nashwa M NM Elgemeie Galal H GH
ACS omega 20200806 32
A series of pyrimidine and pyrimidine thioglycoside derivatives were newly synthesized using sodium 2-cyano-3-(arylamino)prop-1-ene-1,1-bis(thiolates) and urea to give the corresponding sodium 6-amino-5-aryl-2-oxo-1,2-dihydropyrimidine-4-thiolates. Stirring of the latter with peracetylated α-d-gluco- and galacto-pyranosyl bromides in DMF afforded the corresponding pyrimidine thioglycosides. On the other hand, treatment of 6-amino-5-aryl-2-oxo-1,2-dihydropyrimidine-4-thiolate salts with hydrochlo ...[more]