Ontology highlight
ABSTRACT:
SUBMITTER: Levy O
PROVIDER: S-EPMC7439491 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Levy Oren O Kuai Rui R Siren Erika M J EMJ Bhere Deepak D Milton Yuka Y Nissar Nabeel N De Biasio Michael M Heinelt Martina M Reeve Brock B Abdi Reza R Alturki Meshael M Fallatah Mohanad M Almalik Abdulaziz A Alhasan Ali H AH Shah Khalid K Karp Jeffrey M JM
Science advances 20200722 30
More than 1050 clinical trials are registered at FDA.gov that explore multipotent mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable, including neurodegenerative and cardiac disorders, perianal fistulas, graft-versus-host disease, COVID-19, and cancer. Several companies have or are in the process of commercializing MSC-based therapies. However, most of the clinical-stage MSC therapies have been unable to meet primary efficacy end points. The innate therapeutic func ...[more]