Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics.
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ABSTRACT:
SUBMITTER: Lechuga-Vieco AV
PROVIDER: S-EPMC7439646 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics.
Lechuga-Vieco Ana Victoria AV Latorre-Pellicer Ana A Johnston Iain G IG Prota Gennaro G Gileadi Uzi U Justo-Méndez Raquel R Acín-Pérez Rebeca R Martínez-de-Mena Raquel R Fernández-Toro Jose María JM Jimenez-Blasco Daniel D Mora Alfonso A Nicolás-Ávila Jose A JA Santiago Demetrio J DJ Priori Silvia G SG Bolaños Juan Pedro JP Sabio Guadalupe G Criado Luis Miguel LM Ruíz-Cabello Jesús J Cerundolo Vincenzo V Jones Nick S NS Enríquez José Antonio JA
Science advances 20200729 31
Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic mice with nonpathological mtDNA variants reveal a nonrandom tissue-specific mtDNA segregation pattern, with few tissues that do not show segregation. The driving force for this dynamic complex pattern has remained unexplained for decades, challenging our understanding of th ...[more]
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