Ontology highlight
ABSTRACT:
SUBMITTER: Khullar K
PROVIDER: S-EPMC7439775 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Oncology & hematology review 20200427 1
Locally advanced rectal cancer has broadly been defined as T3, T4, or lymph node-positive disease. In the 1990s, adjuvant chemoradiation was considered the optimal management for locally advanced rectal cancer. However, the paradigm shifted when the German CAO/ARO/AIO-94 Rectal Cancer trial established neoadjuvant chemoradiation as the standard of care, based on reduced rates of toxicity and local recurrence, as well as higher rates of sphincter preservation compared with postoperative chemoradi ...[more]