Role of the DEK oncogene in the development of squamous cell carcinoma.
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ABSTRACT:
SUBMITTER: Ishida K
PROVIDER: S-EPMC7441080 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Role of the DEK oncogene in the development of squamous cell carcinoma.
Ishida Kazuhisa K Nakashima Takayuki T Shibata Toshiyuki T Hara Akira A Tomita Hiroyuki H
International journal of clinical oncology 20200712 9
DEK is a highly conserved nuclear factor that plays an important role in the regulation of multiple cellular processes. DEK was discovered to be an oncogene as a fusion with NUP214 gene, which results in producing DEK-NUP214 proteins, in a subset of patients with acute myeloid leukemia. Subsequently, DEK overexpression was reported in many cancers, thus DEK itself is considered to be an oncoprotein. DEK has been reported to play important roles in the progression of early and late stage squamous ...[more]
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