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The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension.


ABSTRACT: Pulmonary hypertension (PH) is one of the most devastating cardiovascular diseases worldwide and it draws much attention from numerous scientists. As an indispensable part of pulmonary artery, smooth muscle cells are worthy of being carefully investigated. To elucidate the pathogenesis of PH, several theories focusing on pulmonary artery smooth muscle cells (PASMC), such as hyperproliferation, resistance to apoptosis, and cancer theory, have been proposed and widely studied. Here, we tried to summarize the studies, concentrating on the role of PASMC in the development of PH, feasible molecular basis to intervene, and potential treatment to PH.

SUBMITTER: He S 

PROVIDER: S-EPMC7441461 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension.

He Shixin S   Zhu Tengteng T   Fang Zhenfei Z  

International journal of hypertension 20200811


Pulmonary hypertension (PH) is one of the most devastating cardiovascular diseases worldwide and it draws much attention from numerous scientists. As an indispensable part of pulmonary artery, smooth muscle cells are worthy of being carefully investigated. To elucidate the pathogenesis of PH, several theories focusing on pulmonary artery smooth muscle cells (PASMC), such as hyperproliferation, resistance to apoptosis, and cancer theory, have been proposed and widely studied. Here, we tried to su  ...[more]

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