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Childhood perfluoroalkyl substance exposure and executive function in children at 8?years.


ABSTRACT: BACKGROUND:Toxicological studies highlight the potential neurotoxicity of perfluoroalkyl substances (PFAS) during fetal development. However, few epidemiological studies have examined the impact of childhood PFAS on neurodevelopment. METHODS:We employed data from 208 children in the Health Outcomes and Measures of the Environment Study, a birth cohort (Cincinnati, OH), to examine associations of six serum PFAS concentrations measured at 3 and 8?years with executive function assessed at 8?years using the validated parent-completed Behavior Rating Inventory of Executive Function survey. We used multiple informant models to identify susceptible windows of neurotoxicity to PFAS and executive function. We investigated trajectories of PFAS concentrations and whether sex modified these associations. RESULTS:Each ln-increase in perfluorononanoate (PFNA) at 8?years was associated with a 3.4-point increase (95% CI 0.4, 6.3) in metacognition score, indicating poorer function. Children with PFNA above the median at 8?years had poorer global executive functioning compared to children with concentrations consistently below median levels (??=?6.5, 95% CI 0.2, 12.9). Higher concurrent PFNA was associated with poorer behavior regulation among males, while associations among females were null (pPFNA×sex?=?0.018). Children with higher concurrent perfluorooctanoate (PFOA) had increased odds of being at risk of having clinical impairments in metacognition (OR?=?3.18, 95% CI 1.17, 8.60). There were no associations between perfluorooctane sulfonate and perfluorohexane sulfonate and executive function. CONCLUSIONS:PFNA and PFOA at 8?years, but not 3?years, may be related to poorer executive function at 8?years. Results need to be confirmed in cohort studies with larger sample sizes.

SUBMITTER: Vuong AM 

PROVIDER: S-EPMC7442288 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Childhood perfluoroalkyl substance exposure and executive function in children at 8 years.

Vuong Ann M AM   Yolton Kimberly K   Wang Zhiyang Z   Xie Changchun C   Webster Glenys M GM   Ye Xiaoyun X   Calafat Antonia M AM   Braun Joseph M JM   Dietrich Kim N KN   Lanphear Bruce P BP   Chen Aimin A  

Environment international 20180704


<h4>Background</h4>Toxicological studies highlight the potential neurotoxicity of perfluoroalkyl substances (PFAS) during fetal development. However, few epidemiological studies have examined the impact of childhood PFAS on neurodevelopment.<h4>Methods</h4>We employed data from 208 children in the Health Outcomes and Measures of the Environment Study, a birth cohort (Cincinnati, OH), to examine associations of six serum PFAS concentrations measured at 3 and 8 years with executive function assess  ...[more]

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