Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis.

ABSTRACT:

Background

The etiological basis of glioma is poorly understood. We have used genetic markers in a Mendelian randomization (MR) framework to examine if lifestyle, cardiometabolic, and inflammatory factors influence the risk of glioma. This methodology reduces bias from confounding and is not affected by reverse causation.

Methods

We identified genetic instruments for 37 potentially modifiable risk factors and evaluated their association with glioma risk using data from a genome-wide association study of 12 488 glioma patients and 18 169 controls. We used the estimated odds ratio of glioma associated with each of the genetically defined traits to infer evidence for a causal relationship with the following exposures:Lifestyle and dietary factors-height, plasma insulin-like gro

SUBMITTER: Saunders CN 

PROVIDER: S-EPMC7442418 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature