Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC7442472 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Yang Sidi S Arrode-Bruses Geraldine G Frank Ines I Grasperge Brooke B Blanchard James J Gettie Agegnehu A Martinelli Elena E Ho Emmanuel A EA
Science advances 20200821 34
Intravenous administration of anti-α<sub>4</sub>β<sub>7</sub> monoclonal antibody in macaques decreases simian immunodeficiency virus (SIV) vaginal infection and reduces gut SIV loads. Because of potential side effects of systemic administration, a prophylactic strategy based on mucosal administration of anti-α<sub>4</sub>β<sub>7</sub> antibody may be safer and more effective. With this in mind, we developed a novel intravaginal formulation consisting of anti-α<sub>4</sub>β<sub>7</sub> monoclona ...[more]