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Association of obesity and its genetic predisposition with the risk of severe COVID-19: Analysis of population-based cohort data.


ABSTRACT: OBJECTIVE:We aimed to examine the associations of obesity-related traits (body mass index [BMI], central obesity) and their genetic predisposition with the risk of developing severe COVID-19 in a population-based data. RESEARCH DESIGN AND METHODS:We analyzed data from 489,769 adults enrolled in the UK Biobank-a population-based cohort study. The exposures of interest are BMI categories and central obesity (e.g., larger waist circumference). Using genome-wide genotyping data, we also computed polygenic risk scores (PRSs) that represent an individual's overall genetic risk for each obesity trait. The outcome was severe COVID-19, defined by hospitalization for laboratory-confirmed COVID-19. RESULTS:Of 489,769 individuals, 33% were normal weight (BMI, 18.5-24.9?kg/m2), 43% overweight (25.0-29.9?kg/m2), and 24% obese (?30.0?kg/m2). The UK Biobank identified 641 patients with severe COVID-19. Compared to adults with normal weight, those with a higher BMI had a dose-response increases in the risk of severe COVID-19, with the following adjusted ORs: for 25.0-29.9?kg/m2, 1.40 (95%CI 1.14-1.73; P?=?0.002); for 30.0-34.9?kg/m2, 1.73 (95%CI 1.36-2.20; P?

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC7442576 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Association of obesity and its genetic predisposition with the risk of severe COVID-19: Analysis of population-based cohort data.

Zhu Zhaozhong Z   Hasegawa Kohei K   Ma Baoshan B   Fujiogi Michimasa M   Camargo Carlos A CA   Liang Liming L  

Metabolism: clinical and experimental 20200822


<h4>Objective</h4>We aimed to examine the associations of obesity-related traits (body mass index [BMI], central obesity) and their genetic predisposition with the risk of developing severe COVID-19 in a population-based data.<h4>Research design and methods</h4>We analyzed data from 489,769 adults enrolled in the UK Biobank-a population-based cohort study. The exposures of interest are BMI categories and central obesity (e.g., larger waist circumference). Using genome-wide genotyping data, we al  ...[more]

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