Use of a Polygenic Risk Score Improves Prediction of Myocardial Injury After Non-Cardiac Surgery.

ABSTRACT:

Background

While postoperative myocardial injury remains a major driver of morbidity and mortality, the ability to accurately identify patients at risk remains limited despite decades of clinical research. The role of genetic information in predicting myocardial injury after noncardiac surgery (MINS) remains unknown and requires large scale electronic health record and genomic data sets.

Methods

In this retrospective observational study of adult patients undergoing noncardiac surgery, we defined MINS as new troponin elevation within 30 days following surgery. To determine the incremental value of polygenic risk score (PRS) for coronary artery disease, we added the score to 3 models of MINS risk: revised cardiac risk index, a model comprised entirely of preoperative variables

SUBMITTER: Douville NJ 

PROVIDER: S-EPMC7442662 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature