Ontology highlight
ABSTRACT:
SUBMITTER: Laidlaw BJ
PROVIDER: S-EPMC7442689 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Laidlaw Brian J BJ Duan Lihui L Xu Ying Y Vazquez Sara E SE Cyster Jason G JG
Nature immunology 20200629 9
Memory B cells (MBCs) are essential for long-lived humoral immunity. However, the transcription factors involved in MBC differentiation are poorly defined. Here, using single-cell RNA sequencing analysis, we identified a population of germinal center (GC) B cells in the process of differentiating into MBCs. Using an inducible CRISPR-Cas9 screening approach, we identified the hematopoietically expressed homeobox protein Hhex as a transcription factor regulating MBC differentiation. The corepresso ...[more]