The quest for improving the management of breast cancer by functional imaging: The discovery and development of 16α-[¹⁸F]fluoroestradiol (FES), a PET radiotracer for the estrogen receptor, a historical review.

ABSTRACT:

Introduction

16α-[¹⁸F]Fluoroestradiol (FES), a PET radiotracer for the estrogen receptor (ER) in breast cancer, was the first receptor-targeted PET radiotracer for oncology and is continuing to prove its value in clinical research, antiestrogen development, and breast cancer care. The story of its conception, design, evaluation and use in clinical studies parallels the evolution of the whole field of receptor-targeted radiotracers, one greatly influenced by the research and intellectual contributions of William C. Eckelman.

Methods and results

The development of methods for efficient production of fluorine-18, for conversion of [¹⁸F]fluoride ion into chemically reactive form, and for its rapid and efficient incorporation into suitable estrogen precursor

SUBMITTER: Katzenellenbogen JA 

PROVIDER: S-EPMC7442693 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature