Ontology highlight
ABSTRACT:
SUBMITTER: Lake RJ
PROVIDER: S-EPMC7442708 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Lake Robert J RJ Haynes Mark K MK Dreval Kostiantyn K Bilkis Rabeya R Sklar Larry A LA Fan Hua-Ying HY
SLAS discovery : advancing life sciences R & D 20200622 8
Notch signaling is often involved in cancer cell initiation and proliferation. Aberrant Notch activation underlies more than 50% of T-cell acute lymphoblastic leukemia (T-ALL); accordingly, chemicals disrupting Notch signaling are of potential to treat Notch-dependent cancer. Here, we developed a flow cytometry-based high-throughput assay to identify compounds that disrupt the interactions of DNA and RBPJ, the major downstream effector of Notch signaling. From 1492 compounds, we identified 18 co ...[more]