Ontology highlight
ABSTRACT:
SUBMITTER: Ho WJ
PROVIDER: S-EPMC7442729 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Ho Won Jin WJ Jaffee Elizabeth M EM Zheng Lei L
Nature reviews. Clinical oncology 20200512 9
Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes have fuelled ongoing efforts to exploit the tumour microenvironment (TME) for therapy, but strategies aimed at deconstructing the surrounding desmoplastic stroma and targeting the immunosuppressive pathways have largely failed. In fact, evidence has now shown that the stroma is multi-faceted, which illustrates the complex ...[more]