Glycovariant-based lateral flow immunoassay to detect ovarian cancer-associated serum CA125.
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ABSTRACT:
SUBMITTER: Bayoumy S
PROVIDER: S-EPMC7442799 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Glycovariant-based lateral flow immunoassay to detect ovarian cancer-associated serum CA125.
Bayoumy Sherif S Bayoumy Sherif S Hyytiä Heidi H Leivo Janne J Talha Sheikh M SM Huhtinen Kaisa K Poutanen Matti M Hynninen Johanna J Perheentupa Antti A Lamminmäki Urpo U Gidwani Kamlesh K Pettersson Kim K
Communications biology 20200821 1
Cancer antigen 125 (CA125) is a widely used biomarker in monitoring of epithelial ovarian cancer (EOC). Due to insufficient cancer specificity of CA125, its diagnostic use is severely compromised. Abnormal glycosylation of CA125 is a unique feature of ovarian cancer cells and could improve differential diagnosis of the disease. Here we describe the development of a quantitative lateral flow immunoassay (LFIA) of aberrantly glycosylated CA125 which is widely superior to the conventional CA125 imm ...[more]
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