Ontology highlight
ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC7442809 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Wu Qin Q Ba-Alawi Wail W Deblois Genevieve G Cruickshank Jennifer J Duan Shili S Lima-Fernandes Evelyne E Haight Jillian J Tonekaboni Seyed Ali Madani SAM Fortier Anne-Marie AM Kuasne Hellen H McKee Trevor D TD Mahmoud Hassan H Kushida Michelle M Cameron Sarina S Dogan-Artun Nergiz N Chen WenJun W Nie Yan Y Zhang Lan Xin LX Vellanki Ravi N RN Zhou Stanley S Prinos Panagiotis P Wouters Bradly G BG Dirks Peter B PB Done Susan J SJ Park Morag M Cescon David W DW Haibe-Kains Benjamin B Lupien Mathieu M Arrowsmith Cheryl H CH
Nature communications 20200821 1
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expression of glucose transporter 1 (GLUT1, encoded by SLC2A1) and associated metabolic dependencies in TNBC, we investigated the vulnerability of TNBC cell lines and patient-derived samples to GLUT1 inhibition. We report that genetic or pharmacological in ...[more]