Screening and Enrollment by Sex in Human Immunodeficiency Virus Clinical Trials in the United States.

ABSTRACT:

Background

Women are underrepresented in human immunodeficiency virus (HIV) research in the United States. To determine if women screening for HIV clinical trials enrolled at lower rates than men, we performed a retrospective, cross-trial analysis.

Methods

We conducted an analysis of screening and enrollment during 2003-2013 to 31 clinical trials at 99 AIDS Clinical Trials Group network research sites in the United States. Random-effects meta regression estimated whether sex differences in not enrolling ("screen out") varied by various individual, trial, or site characteristics.

Results

Of 10 744 persons screened, 18.9% were women. The percentages of women and men who screened out were 27.9% and 26.5%, respectively (P = .19); this small difference did not significantl

SUBMITTER: Smeaton LM 

PROVIDER: S-EPMC7442845 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature