Dataset Information

Systematic analysis of disease-specific immunological signatures in patients with febrile illness from Saudi Arabia.

ABSTRACT: Objectives:Little is known about the prevalence of febrile illness in the Arabian region as clinical, laboratory and immunological profiling remains largely uncharacterised. Methods:A total of 2018 febrile patients from Jazan, Saudi Arabia, were recruited between 2014 and 2017. Patients were screened for dengue and chikungunya virus, Plasmodium, Brucella, Neisseria meningitidis, group A streptococcus and Leptospira. Clinical history and biochemical parameters from blood tests were collected. Patient sera of selected disease-confirmed infections were quantified for immune mediators by multiplex microbead-based immunoassays. Results:Approximately 20% of febrile patients were tested positive for one of the pathogens, and they presented overlapping clinical and laboratory parameters. Nonetheless, eight disease-specific immune mediators were identified as potential biomarkers for dengue (MIP-1?, MCP-1), malaria (TNF-?), streptococcal and meningococcal (eotaxin, GRO-?, RANTES, SDF-1? and PIGF-1) infections, with high specificity and sensitivity profiles. Notably, based on the conditional inference model, six of these mediators (MIP-1?, TNF-?, GRO-?, RANTES, SDF-1? and PIGF-1) were revealed to be 68.4% accurate in diagnosing different febrile infections, including those of unknown diseases. Conclusions:This study is the first extensive characterisation of the clinical analysis and immune biomarkers of several clinically important febrile infections in Saudi Arabia. Importantly, an immune signature with robust accuracy, specificity and sensitivity in differentiating several febrile infections was identified, providing useful insights into patient disease management in the Arabian Peninsula.

SUBMITTER: Kam YW

PROVIDER: S-EPMC7443187 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Systematic analysis of disease-specific immunological signatures in patients with febrile illness from Saudi Arabia.

Kam Yiu-Wing YW Ahmed Mohamed Yousif MY Amrun Siti Naqiah SN Lee Bernett B Refaie Tarik T Elgizouli Kamla K Fong Siew-Wai SW Renia Laurent L Ng Lisa Fp LF

Clinical & translational immunology 20200822 8

<h4>Objectives</h4>Little is known about the prevalence of febrile illness in the Arabian region as clinical, laboratory and immunological profiling remains largely uncharacterised.<h4>Methods</h4>A total of 2018 febrile patients from Jazan, Saudi Arabia, were recruited between 2014 and 2017. Patients were screened for dengue and chikungunya virus, <i>Plasmodium</i>, <i>Brucella</i>, <i>Neisseria meningitidis</i>, group A streptococcus and <i>Leptospira</i>. Clinical history and biochemical para ...[more]

PMID: 32864128

Similar Datasets

Project description:BackgroundDespite allergic rhinitis (AR) being a highly prevalent disease, according to literature, it is often underdiagnosed or undertreated.AimThis study explored the disease characteristics of AR in the Saudi community and the non-conventional coping measures used to alleviate symptoms.MethodsThe study was a nationwide cross-sectional study, using a self-report electronic survey distributed via social media networks in 2018. The survey included an explanatory letter and consent. The sample size comprised 3,458 participants and 2,849 adults had at least one of the four signs of AR, i.e. watery-nose, sneezing, nasal obstruction, itchy nose, watery eyes, in the past year, not related to cold/flu. The outcomes of the study were the triggers, pattern, severity and the classification of AR (2016 ARIA guidelines) and coping measures. Descriptive statistics, univariate analytic statistics and binary logistic regression analyses were conducted. The P-value was considered statistically significant at <0.05.ResultsThe leading reported trigger of AR was dust (74%, n = 2118), followed by pollen (17%, n = 477), mold (5%, n = 140) and fur (4%, n = 114). The prevalence of intermittent AR was (54%, n = 1,635), while that of persistent AR was (46%, n = 1,314). Almost one-third (34%, n = 959) complained of mild forms of AR, while others complained of moderate to severe forms (66%, n = 1890). The coping measures were mainly shower/humidification 368(12.9%) and herbal hot drinks 266(9.3%). Older participants (adj.OR = 1.3[1.1-1.5]) and overweight participants, (adj.OR = 1.2[1.1-1.4]) reported more persistent forms of rhinitis compared to their counter groups, (adj.P<0.001 and adj.P = 0.032) respectively. Female participants (adj.OR = 0.8[0.7-0.9]) had significantly milder forms of AR, in comparison to males, adj.P = 0.006.ConclusionThis study presented the disease characteristics of self-reported AR and its associated factors in Saudi Arabia. Special attention should be paid to older age groups and overweight patients who reported persistent forms of AR. Males reported more severe and persistent forms of AR.

Dataset Information

Systematic analysis of disease-specific immunological signatures in patients with febrile illness from Saudi Arabia.

Publications

Systematic analysis of disease-specific immunological signatures in patients with febrile illness from Saudi Arabia.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure