An UPLC-MS/MS Method for Simultaneous Quantification of the Components of Shenyanyihao Oral Solution in Rat Plasma.

ABSTRACT:

Objectives

To study the quantification of the components in rat plasma after oral administration of Shenyanyihao oral solution.

Methods

Shenyanyihao oral solution has been traditionally used for the treatments of chronic nephritis in clinics. Stachydrine, Danshensu, chlorogenic acid, protocatechuic acid, plantamajoside, aesculetin, isoquercitrin, ferulic acid, baicalin, and baicalein are regarded as the main compounds in Shenyanyihao oral solution. A sensitive, efficient, and precise UPLC-MS/MS method was established and validated for the quantification of the components in rat plasma after oral administration of Shenyanyihao oral solution.

Results

The main pharmacokinetic parameters of the components were acquired based on the analysis of the plasma sample by a nonco

SUBMITTER: Jiang C 

PROVIDER: S-EPMC7443224 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature