Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents.

ABSTRACT:

Objective

Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment.

Methods

In this retrospective cohort study, we observed 783 short children and adolescents, 229 of whom received GH therapy. Skeletal maturation was assessed based on the difference between bone age (BA) and chronological age (CA) (noted as BA-CA). Anthropometric data and laboratory values were measured, and BA was evaluated using the Greulich and Pyle method.

Results

The delayed BA group was defined as BA-CA < -2 SD (n = 457), and the occurrence rate of BA delay was 58.3

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC7443236 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature