Rational ligand choice extends the SABRE substrate scope.
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ABSTRACT: Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate 1H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant enhancements for provitamin B6 and caffeine. We also show 15N-enhancements of ∼1000-fold and 19F-enhancements of 30-fold.
SUBMITTER: Colell JFP
PROVIDER: S-EPMC7443256 | biostudies-literature |
REPOSITORIES: biostudies-literature
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