ErbB in NSCLC as a molecular target: current evidences and future directions.
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ABSTRACT:
SUBMITTER: Del Re M
PROVIDER: S-EPMC7443272 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
erbB in NSCLC as a molecular target: current evidences and future directions.
Del Re Marzia M Cucchiara Federico F Petrini Iacopo I Fogli Stefano S Passaro Antonio A Crucitta Stefania S Attili Ilaria I De Marinis Filippo F Chella Antonio A Danesi Romano R
ESMO open 20200801 4
A number of treatments have been developed for HER1, 2 and 3-driven non-small cell lung cancer (NSCLC), of which the most successful have been the epidermal growth factor receptor-tyrosine kinase inhibitors in HER1-mutant tumours resulting in highly improved progression-free survival. Human epidermal growth factor (HER)2 and 3-driven tumours represent the minority of NSCLC, and effective therapies in these patients still represent an unmet medical need. The encouraging results seen with anti-HER ...[more]
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