Widespread receptor-driven modulation in peripheral olfactory coding.
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ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC7443284 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Widespread receptor-driven modulation in peripheral olfactory coding.
Xu Lu L Li Wenze W Voleti Venkatakaushik V Zou Dong-Jing DJ Hillman Elizabeth M C EMC Firestein Stuart S
Science (New York, N.Y.) 20200401 6487
Olfactory responses to single odors have been well characterized but in reality we are continually presented with complex mixtures of odors. We performed high-throughput analysis of single-cell responses to odor blends using Swept Confocally Aligned Planar Excitation (SCAPE) microscopy of intact mouse olfactory epithelium, imaging ~10,000 olfactory sensory neurons in parallel. In large numbers of responding cells, mixtures of odors did not elicit a simple sum of the responses to individual compo ...[more]
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