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Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2.

ABSTRACT: The world is in the midst of a pandemic caused by a novel coronavirus and is desperately searching for possible treatments. The antiviral remdesivir has shown some effectiveness against SARS-CoV-2 in vitro and in a recent animal study. We use data from a study of remdesivir in rhesus macaques to fit a viral kinetics model in an effort to determine the most appropriate mathematical descripton of the effect of remdesivir. We find statistically significant differences in the viral decay rate and use this to inform a possible mathematical formulation of the effect of remdesivir. Unfortunately, this model formulation suggests that the application of remdesivir will lengthen SARS-CoV-2 infections, putting into question its potential clinical benefit.

SUBMITTER: Dobrovolny HM

PROVIDER: S-EPMC7443325 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2.

Dobrovolny Hana M HM

Virology 20200823

The world is in the midst of a pandemic caused by a novel coronavirus and is desperately searching for possible treatments. The antiviral remdesivir has shown some effectiveness against SARS-CoV-2 in vitro and in a recent animal study. We use data from a study of remdesivir in rhesus macaques to fit a viral kinetics model in an effort to determine the most appropriate mathematical descripton of the effect of remdesivir. We find statistically significant differences in the viral decay rate and us ...[more]

PMID: 32882638

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