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Deactivation of SARS-CoV-2 with pulsed-xenon ultraviolet light: Implications for environmental COVID-19 control.


ABSTRACT: OBJECTIVES:Prolonged survival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on environmental surfaces and personal protective equipment may lead to these surfaces transmitting this pathogen to others. We sought to determine the effectiveness of a pulsed-xenon ultraviolet (PX-UV) disinfection system in reducing the load of SARS-CoV-2 on hard surfaces and N95 respirators. METHODS:Chamber slides and N95 respirator material were directly inoculated with SARS-CoV-2 and were exposed to different durations of PX-UV. RESULTS:For hard surfaces, disinfection for 1, 2, and 5 minutes resulted in 3.53 log10, >4.54 log10, and >4.12 log10 reductions in viral load, respectively. For N95 respirators, disinfection for 5 minutes resulted in >4.79 log10 reduction in viral load. PX-UV significantly reduced SARS-CoV-2 on hard surfaces and N95 respirators. CONCLUSION:With the potential to rapidly disinfectant environmental surfaces and N95 respirators, PX-UV devices are a promising technology to reduce environmental and personal protective equipment bioburden and to enhance both healthcare worker and patient safety by reducing the risk of exposure to SARS-CoV-2.

SUBMITTER: Simmons SE 

PROVIDER: S-EPMC7443558 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Deactivation of SARS-CoV-2 with pulsed-xenon ultraviolet light: Implications for environmental COVID-19 control.

Simmons Sarah E SE   Carrion Ricardo R   Alfson Kendra J KJ   Staples Hilary M HM   Jinadatha Chetan C   Jarvis William R WR   Sampathkumar Priya P   Chemaly Roy F RF   Khawaja Fareed F   Povroznik Mark M   Jackson Stephanie S   Kaye Keith S KS   Rodriguez Robert M RM   Stibich Mark A MA  

Infection control and hospital epidemiology 20200803 2


<h4>Objectives</h4>Prolonged survival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on environmental surfaces and personal protective equipment may lead to these surfaces transmitting this pathogen to others. We sought to determine the effectiveness of a pulsed-xenon ultraviolet (PX-UV) disinfection system in reducing the load of SARS-CoV-2 on hard surfaces and N95 respirators.<h4>Methods</h4>Chamber slides and N95 respirator material were directly inoculated with SARS-CoV-2 an  ...[more]

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