CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors.
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ABSTRACT: Introduction
Glucose hypometabolism and tau formation are key features of Alzheimer's disease (AD). Less is known about the relationship between fasting glucose and regional tau accumulation.Methods
Cerebrospinal fluid (CSF) glucose was linearly regressed on regional tau (flortaucipir) among 169 Alzheimer's Disease Neuroimaging Initiative (ADNI3) participants. Flortaucipir uptake was examined by Braak stages and regions of interest (ROIs). Interactions were explored between CSF glucose and AD risk factors including regional amyloid beta (Aβ), sex, Apolipoprotein E ε4 (APOEε4) status, AD parental family history (AD FH), and cognitive impairment (CI).Results
Interactions found higher CSF glucose tracked less tau in ROIs or Braak stages I/II (women, APOE ε4+, regional Aβ), III/IV (AD FH+, regional Aβ), and V/VI (AD FH+). CI drove Braak III-VI associations.Discussion
Among women and APOE ε4 carriers, higher CSF glucose tracked less early-stage tau. Higher CSF glucose may reflect compensation against tau spreading in CI, Aβ+, or AD FH+.
SUBMITTER: Pappas C
PROVIDER: S-EPMC7443745 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors.
Pappas Colleen C Klinedinst Brandon S BS Le Scott S Wang Qian Q Larsen Brittany B McLimans Kelsey K Lockhart Samuel N SN Allenspach-Jorn Karin K Mochel Jonathan P JP Willette Auriel A AA
Alzheimer's & dementia (New York, N. Y.) 20200824 1
<h4>Introduction</h4>Glucose hypometabolism and tau formation are key features of Alzheimer's disease (AD). Less is known about the relationship between fasting glucose and regional tau accumulation.<h4>Methods</h4>Cerebrospinal fluid (CSF) glucose was linearly regressed on regional tau (flortaucipir) among 169 Alzheimer's Disease Neuroimaging Initiative (ADNI3) participants. Flortaucipir uptake was examined by Braak stages and regions of interest (ROIs). Interactions were explored between CSF g ...[more]
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