CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors.
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ABSTRACT:
SUBMITTER: Pappas C
PROVIDER: S-EPMC7443745 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors.
Pappas Colleen C Klinedinst Brandon S BS Le Scott S Wang Qian Q Larsen Brittany B McLimans Kelsey K Lockhart Samuel N SN Allenspach-Jorn Karin K Mochel Jonathan P JP Willette Auriel A AA
Alzheimer's & dementia (New York, N. Y.) 20200824 1
<h4>Introduction</h4>Glucose hypometabolism and tau formation are key features of Alzheimer's disease (AD). Less is known about the relationship between fasting glucose and regional tau accumulation.<h4>Methods</h4>Cerebrospinal fluid (CSF) glucose was linearly regressed on regional tau (flortaucipir) among 169 Alzheimer's Disease Neuroimaging Initiative (ADNI3) participants. Flortaucipir uptake was examined by Braak stages and regions of interest (ROIs). Interactions were explored between CSF g ...[more]
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