Ontology highlight
ABSTRACT:
SUBMITTER: Gerhauser C
PROVIDER: S-EPMC7444093 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Cancer cell 20181201 6
Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Our ...[more]