Transplantation of Endothelial Progenitor Cells in the Treatment of Coronary Artery Microembolism in Rats.

ABSTRACT: As the impairment of myocardial microenvironments due to coronary microembolization (CME) compromises the treatment effect of percutaneous coronary intervention and leads to adverse prognosis, we hypothesized that endothelial progenitor cells (EPCs) transplantation could improve cardiac function in the condition of CME. Low- (2 × 10⁵) and high- (2 × 10⁶) dose rat bone marrow-derived EPCs were transplanted in a model of CME. To develop a CME model, rats were injected with autologous micro-blood-clots into the left ventricle. Echocardiograph was examined before and 1, 7, and 28 days after EPC transplantation; serum cardiac troponin I (cTNI), von Willebrand factor (vWF), and cardiac microRNA expression were examined one day after EPCs transplantation. Heart morphology an

SUBMITTER: Xue Y 

PROVIDER: S-EPMC7444210 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature