Brain tocopherol levels are associated with lower activated microglia density in elderly human cortex.
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ABSTRACT:
SUBMITTER: de Leeuw FA
PROVIDER: S-EPMC7444784 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Brain tocopherol levels are associated with lower activated microglia density in elderly human cortex.
de Leeuw Francisca A FA Schneider Julie A JA Agrawal Sonal S Leurgans Sue E SE Morris Martha Clare MC
Alzheimer's & dementia (New York, N. Y.) 20200824 1
<h4>Introduction</h4>Higher brain tocopherol levels have been associated with lower levels of Alzheimer's disease (AD) neuropathology; however, the underlying mechanisms are unclear.<h4>Methods</h4>We studied the relations of α- and γ-tocopherol brain levels to microglia density in 113 deceased participants from the Memory and Aging Project. We used linear regression analyses to examine associations between tocopherol levels and microglia densities in a basic model adjusted for age, sex, educati ...[more]
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