Ontology highlight
ABSTRACT:
SUBMITTER: Starich TA
PROVIDER: S-EPMC7445009 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Starich Todd A TA Bai Xiaofei X Greenstein David D
eLife 20200731
Gap junctions are ubiquitous in metazoans and play critical roles in important biological processes, including electrical conduction and development. Yet, only a few defined molecules passing through gap junction channels have been linked to specific functions. We isolated gap junction channel mutants that reduce coupling between the soma and germ cells in the <i>Caenorhabditis elegans</i> gonad. We provide evidence that malonyl-CoA, the rate-limiting substrate for fatty acid synthesis (FAS), is ...[more]