Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.

ABSTRACT: Alzheimer's disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function¹. However, little is known about the contribution of the adaptive immune response in Alzheimer's disease². Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer's disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer's disease that consists of increased numbers of CD8⁺ T effector memory CD45RA⁺ (T_EMRA) cells. In a second cohort, we found that CD8⁺ T_EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T c

SUBMITTER: Gate D 

PROVIDER: S-EPMC7445078 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature