Ontology highlight
ABSTRACT:
SUBMITTER: Al Abed AS
PROVIDER: S-EPMC7445258 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nature communications 20200824 1
Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, we show in mice that contextual amnesia is causally involved in PTSD-like memory formation, and that treating the amnesia by re-exposure to all trauma-related cues cures PTSD-like hypermnesia. These findings open a therapeutic perspective based on t ...[more]