Ontology highlight
ABSTRACT:
SUBMITTER: Jin JH
PROVIDER: S-EPMC7445287 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nature communications 20200824 1
Phosphatases, together with kinases and transcription factors, are key components in cellular signalling networks. Here, we present a systematic functional analysis of the phosphatases in Cryptococcus neoformans, a fungal pathogen that causes life-threatening fungal meningoencephalitis. We analyse 230 signature-tagged mutant strains for 114 putative phosphatases under 30 distinct in vitro growth conditions, revealing at least one function for 60 of these proteins. Large-scale virulence and infec ...[more]