Ontology highlight
ABSTRACT:
SUBMITTER: Oatley P
PROVIDER: S-EPMC7445750 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Oatley Peter P Kirk Joseph A JA Ma Shuwen S Jones Simon S Fagan Robert P RP
Scientific reports 20200824 1
Surface layers (S-layers) are protective protein coats which form around all archaea and most bacterial cells. Clostridium difficile is a Gram-positive bacterium with an S-layer covering its peptidoglycan cell wall. The S-layer in C. difficile is constructed mainly of S-layer protein A (SlpA), which is a key virulence factor and an absolute requirement for disease. S-layer biogenesis is a complex multi-step process, disruption of which has severe consequences for the bacterium. We examined the s ...[more]