Association analysis of rs1695 and rs1138272 variations in GSTP1 gene and breast cancer susceptibility.

ABSTRACT:

Background

The glutathione S transferases P1 (GSTP1) is one of the common type of the GSTs family. This gene has several genetic polymorphisms that the rs1695 and rs1138272 are the most common variations in this gene. This study aimed to examine the association of these genetic variations with breast cancer risk which was followed by bioinformatics analysis.

Material and methods

In a case-control study, 200 participants including 100 women with breast cancer and 100 healthy women were enrolled. After blood sample collection and DNA extraction, the total genomic DNA was extracted from this sample. The SNPeffects online software was employed to evaluate the effects of rs1695 genetic variation on the GSTP1 protein structure.

Results

Our data revealed that there is a sign

SUBMITTER: Farmohammadi A 

PROVIDER: S-EPMC7445978 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature