Radiobiologically derived biphasic fractionation schemes to overcome the effects of tumour hypoxia.

ABSTRACT:

Objective

As a fractionated course of radiotherapy proceeds tumour shrinkage leads to resolution of hypoxia and the initiation of accelerated proliferation of radioresistant cancer cells with better repair capacity. We hypothesise that, in tumours with significant hypoxia, improved tumour control could be achieved with biphasic fractionation schedules that either use acceleration after 3-4 weeks of conventional radiotherapy or deliver a higher proportional dose towards the end of a course of treatment. We conducted a modelling study based on the concept of biological effective dose (BED) comparing such novel regimens with conventional fractionation.

Methods

The comparator conventional fractionation schedule 70 Gy in 35 fractions delivered over 7 weeks was tested against the

SUBMITTER: Joseph N 

PROVIDER: S-EPMC7446001 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature