Ontology highlight
ABSTRACT:
SUBMITTER: Frigault MM
PROVIDER: S-EPMC7446425 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frigault Melanie M MM Markovets Aleksandra A Nuttall Barrett B Kim Kyoung-Mee KM Park Se Hoon SH Gangolli Esha A EA Mortimer Peter G S PGS Hollingsworth Simon J SJ Hong Jung Yong JY Kim Kyung K Kim Seung Tae ST Barrett J Carl JC Lee Jeeyun J
JCO precision oncology 20200324
<h4>Purpose</h4>Some gastric cancers harbor <i>MET</i> gene amplifications that can be targeted by selective MET inhibitors to achieve tumor responses, but resistance eventually develops. Savolitinib, a selective MET inhibitor, is beneficial for treating patients with MET-driven gastric cancer. Understanding the resistance mechanisms is important for optimizing postfailure treatment options.<h4>Patients and methods</h4>Here, we identified the mechanisms of acquired resistance to savolitinib in 3 ...[more]