Dataset Information

CCOG: A web-based cognitive test tool for detecting neurodegenerative disorders.

ABSTRACT:

Introduction

Web-based cognitive tests have potential for standardized screening in neurodegenerative disorders. We examined accuracy and consistency of cCOG, a computerized cognitive tool, in detecting mild cognitive impairment (MCI) and dementia.

Methods

Clinical data of 306 cognitively normal, 120 mild cognitive impairment (MCI), and 69 dementia subjects from three European cohorts were analyzed. Global cognitive score was defined from standard neuropsychological tests and compared to the corresponding estimated score from the cCOG tool containing seven subtasks. The consistency of cCOG was assessed comparing measurements administered in clinical settings and in the home environment.

Results

cCOG produced accuracies (receiver operating characteristic-area under the curve [ROC-AUC]) between 0.71 and 0.84 in detecting MCI and 0.86 and 0.94 in detecting dementia when administered at the clinic and at home. The accuracy was comparable to the results of standard neuropsychological tests (AUC 0.69-0.77 MCI/0.91-0.92 dementia).

Discussion

cCOG provides a promising tool for detecting MCI and dementia with potential for a cost-effective approach including home-based cognitive assessments.

SUBMITTER: Rhodius-Meester HFM

PROVIDER: S-EPMC7446945 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

cCOG: A web-based cognitive test tool for detecting neurodegenerative disorders.

Rhodius-Meester Hanneke F M HFM Paajanen Teemu T Koikkalainen Juha J Mahdiani Shadi S Bruun Marie M Baroni Marta M Lemstra Afina W AW Scheltens Philip P Herukka Sanna-Kaisa SK Pikkarainen Maria M Hall Anette A Hänninen Tuomo T Ngandu Tiia T Kivipelto Miia M van Gils Mark M Hasselbalch Steen Gregers SG Mecocci Patrizia P Remes Anne A Soininen Hilkka H van der Flier Wiesje M WM Lötjönen Jyrki J

Alzheimer's & dementia (Amsterdam, Netherlands) 20200825 1

<h4>Introduction</h4>Web-based cognitive tests have potential for standardized screening in neurodegenerative disorders. We examined accuracy and consistency of cCOG, a computerized cognitive tool, in detecting mild cognitive impairment (MCI) and dementia.<h4>Methods</h4>Clinical data of 306 cognitively normal, 120 mild cognitive impairment (MCI), and 69 dementia subjects from three European cohorts were analyzed. Global cognitive score was defined from standard neuropsychological tests and comp ...[more]

PMID: 32864411

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