Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis.
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ABSTRACT:
SUBMITTER: Idowu TO
PROVIDER: S-EPMC7447424 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis.
Idowu Temitayo O TO Etzrodt Valerie V Seeliger Benjamin B Bolanos-Palmieri Patricia P Thamm Kristina K Haller Hermann H David Sascha S
eLife 20200824
Endothelial Tie2 signaling plays a pivotal role in vascular barrier maintenance at baseline and after injury. We previously demonstrated that a sharp drop in Tie2 expression observed across various murine models of critical illnesses is associated with increased vascular permeability and mortality. Matrix metalloprotease (MMP)-14-mediated Tie2 ectodomain shedding has recently been recognized as a possible mechanism for Tie2 downregulation in sepsis. Here, we identified the exact MMP14-mediated T ...[more]
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