Dopamine is associated with prioritization of reward-associated memories in Parkinson's disease.

ABSTRACT: Patients with Parkinson's disease have reduced reward sensitivity related to dopaminergic neuron loss, which is associated with impairments in reinforcement learning. Increasingly, however, dopamine-dependent reward signals are recognized to play an important role beyond reinforcement learning. In particular, it has been shown that reward signals mediated by dopamine help guide the prioritization of events for long-term memory consolidation. Meanwhile, studies of memory in patients with Parkinson's disease have focused on overall memory capacity rather than what is versus what isn't remembered, leaving open questions about the effect of dopamine replacement on the prioritization of memories by reward and the time-dependence of this effect. The current study sought to fill this gap by testi

SUBMITTER: Sharp ME 

PROVIDER: S-EPMC7447515 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature