Potential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population.

ABSTRACT: Minor allele frequency (MAF) of rs3782886 (BRAP) and rs671 (ALDH2) are reported to be inversely associated with blood pressure. Another study revealed that hematopoietic activity which is evaluated by reticulocytes could influenced on hypertension status partly by indicating activity of endothelial maintenance. Therefore, to evaluate the association between genetic factor and hypertension, influence of hematopoietic activity should be considered. A multi-faced analysis was performed in a simple general elderly population model (1,313 older Japanese aged 60-98 years). Participants were stratified by median values of reticulocytes (5.21 × 10⁴ cells/μL for men and 4.65 × 10⁴ cells/μL for women). Independent of known cardiovascular risk factors, MAF of rs3782886 and rs671

SUBMITTER: Shimizu Y 

PROVIDER: S-EPMC7447746 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature