Ontology highlight
ABSTRACT:
SUBMITTER: Morgan D
PROVIDER: S-EPMC7447758 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Morgan Daniel D Studham Matthew M Tjärnberg Andreas A Weishaupt Holger H Swartling Fredrik J FJ Nordling Torbjörn E M TEM Sonnhammer Erik L L ELL
Scientific reports 20200825 1
The gene regulatory network (GRN) of human cells encodes mechanisms to ensure proper functioning. However, if this GRN is dysregulated, the cell may enter into a disease state such as cancer. Understanding the GRN as a system can therefore help identify novel mechanisms underlying disease, which can lead to new therapies. To deduce regulatory interactions relevant to cancer, we applied a recent computational inference framework to data from perturbation experiments in squamous carcinoma cell lin ...[more]