Ontology highlight
ABSTRACT:
SUBMITTER: Stein H
PROVIDER: S-EPMC7447775 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nature communications 20200825 1
A mechanistic understanding of core cognitive processes, such as working memory, is crucial to addressing psychiatric symptoms in brain disorders. We propose a combined psychophysical and biophysical account of two symptomatologically related diseases, both linked to hypofunctional NMDARs: schizophrenia and autoimmune anti-NMDAR encephalitis. We first quantified shared working memory alterations in a delayed-response task. In both patient groups, we report a markedly reduced influence of previou ...[more]