Ontology highlight
ABSTRACT:
SUBMITTER: Bencze G
PROVIDER: S-EPMC7447799 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Bencze Gyula G Bencze Szilvia S Rivera Keith D KD Watson James D JD Hidvegi Mate M Orfi Laszlo L Tonks Nicholas K NK Pappin Darryl J DJ
Scientific reports 20200825 1
Mitochondrial dysfunction and significant changes in metabolic pathways accompany cancer development and are responsible for maintaining the tumor microenvironment. Normal mitochondria can trigger intrinsic apoptosis by releasing cytochrome c into the cytosol. The survival of malignant cells highly depends on the suppression of this function. We validated that A250, a highly purified fraction of fermented wheat germ extract (FWGE), increases the carbon flux into the mitochondria, the expression ...[more]