Cortical Feedback Decorrelates Olfactory Bulb Output in Awake Mice.

ABSTRACT: The olfactory bulb receives rich glutamatergic projections from the piriform cortex. However, the dynamics and importance of these feedback signals remain unknown. Here, we use multiphoton calcium imaging to monitor cortical feedback in the olfactory bulb of awake mice and further probe its impact on the bulb output. Responses of feedback boutons were sparse, odor specific, and often outlasted stimuli by several seconds. Odor presentation either enhanced or suppressed the activity of boutons. However, any given bouton responded with stereotypic polarity across multiple odors, preferring either enhancement or suppression. Feedback representations were locally diverse and differed in dynamics across bulb layers. Inactivation of piriform cortex increased odor responsiveness and pairwise simil

SUBMITTER: Otazu GH 

PROVIDER: S-EPMC7448302 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature