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Clinical and Genomic Epidemiology of Carbapenem-Nonsusceptible Citrobacter spp. at a Tertiary Health Care Center over 2 Decades.


ABSTRACT: Carbapenem-nonsusceptible Citrobacter spp. (CNSC) are increasingly recognized as health care-associated pathogens. Information regarding their clinical epidemiology, genetic diversity, and mechanisms of carbapenem resistance is lacking. We examined microbiology records of adult patients at the University of Pittsburgh Medical Center (UMPC) Presbyterian Hospital (PUH) from 2000 to 2018 for CNSC, as defined by ertapenem nonsusceptibility. Over this time frame, the proportion of CNSC increased from 4% to 10% (P?=?0.03), as did daily defined carbapenem doses/1,000 patient days (6.52 to 34.5; R 2 = 0.831; P?

SUBMITTER: Babiker A 

PROVIDER: S-EPMC7448640 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Clinical and Genomic Epidemiology of Carbapenem-Nonsusceptible <i>Citrobacter</i> spp. at a Tertiary Health Care Center over 2 Decades.

Babiker Ahmed A   Evans Daniel R DR   Griffith Marissa P MP   McElheny Christi L CL   Hassan Mohamed M   Clarke Lloyd G LG   Mettus Roberta T RT   Harrison Lee H LH   Doi Yohei Y   Shields Ryan K RK   Van Tyne Daria D  

Journal of clinical microbiology 20200824 9


Carbapenem-nonsusceptible <i>Citrobacter</i> spp. (CNSC) are increasingly recognized as health care-associated pathogens. Information regarding their clinical epidemiology, genetic diversity, and mechanisms of carbapenem resistance is lacking. We examined microbiology records of adult patients at the University of Pittsburgh Medical Center (UMPC) Presbyterian Hospital (PUH) from 2000 to 2018 for CNSC, as defined by ertapenem nonsusceptibility. Over this time frame, the proportion of CNSC increas  ...[more]

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