Ontology highlight
ABSTRACT:
SUBMITTER: Yasuike N
PROVIDER: S-EPMC7448683 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
ChemPhotoChem 20190304 6
Photo-controlled affinity reagents seek to provide modular spatiotemporal control of bioactivity by conferring photo-switchability of function on an affinity reagent scaffold. Here we used Rosetta-based computational methods to screen for sites on the Fynomer affinity reagent structure for attachment of photoswitchable cross-linkers. Both established UV-based cross-linkers (azobenzene-iodoacetamide (IAC)) and an azonium-based efficient red light switchable cross-linker, piperazino-tetra-<i>ortho ...[more]