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Novel biologically active polyurea derivatives and its TiO₂-doped nanocomposites.

ABSTRACT: A new series of polyurea derivatives and its nanocomposites were synthesised by the solution polycondensation method through the interaction between 4(2-aminothiazol-4-ylbenzylidene)-4-(tert-butyl) cyclohexanone and diisocyanate compound in pyridine. The PU_1-3 structure was conﬁrmed using Fourier transform-infrared (FTIR) spectroscopy and characterised by solubility, viscometry, gel permeation chromatography (GPC), and X-ray diffraction (XRD) analysis. In addition, PU_1-3 was evaluated by TGA. Polyurea-TiO₂nanocomposites were synthesised using the same technique as that of PU_1-3 by adding TiO₂ as a nanofiller. The thermal properties of PU₂TiO₂a-d were evaluated by TGA. Moreover, the morphological properties of a selected sample were examined by SEM and TEM. In addition, PU_1-3 and PU₂TiO₂a-d were examined for antimicrobial activity against certain bacteria and fungi. The PU_1-3 showed antibacterial activity against some of the tested bacteria and fungi, as did PU₂TiO₂a-d, which increased with the increase in TiO₂ content. Furthermore, molecular docking studies were displayed against all PU_1-3 derivatives against two types of proteins. The results show that the increase in the strength of π-H interactions and H-donors contributed to improved binding of PU2 compared to PU1 andPU_3. The docking of 1KZN against the tested polymers suggests an increase in the docking score of PU_2, then PU₁, and PU₃, which is in agreement with the antibacterial study.

SUBMITTER: Hussein MA

PROVIDER: S-EPMC7448906 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Phase segregation and miscibility of TiOx nanocomposites in Gd-doped ceria solid electrolyte material.

Project description:Electro-chemo-mechanical (ECM) coupling refers to mechanical deformation due to electrochemically driven compositional change in a solid. An ECM actuator producing micrometre-size displacements and long-term stability at room temperature was recently reported, comprising a 20 mol% Gd-doped ceria (20GDC), a solid electrolyte membrane, placed between two working bodies made of TiOx/20GDC (Ti-GDC) nanocomposites with Ti concentration of 38 mol%. The volumetric changes originating from oxidation or reduction in the local TiOx units are hypothesized to be the origin of mechanical deformation in the ECM actuator. Studying the Ti concentration-dependent structural changes in the Ti-GDC nanocomposites is therefore required for (i) understanding the mechanism of dimensional changes in the ECM actuator and (ii) maximizing the ECM response. Here, the systematic investigation of the local structure of the Ti and Ce ions in Ti-GDC over a broad range of Ti concentrations using synchrotron X-ray absorption spectroscopy and X-ray diffraction is reported. The main finding is that, depending on the Ti concentration, Ti atoms either form a cerium titanate or segregate into a TiO2 anatase-like phase. The transition region between these two regimes with Ti(IV) concentration between 19% and 57% contained strongly disordered TiOx units dispersed in 20GDC containing Ce(III) and Ce(IV) and hence rich with oxygen vacancies. As a result, this transition region is proposed to be the most advantageous for developing ECM-active materials.

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Coumarin-piperazine derivatives as biologically active compounds.

Project description:A number of psychiatric disorders, including anxiety, schizophrenia, Parkinson's disease, depression and others CNS diseases are known to induce defects in the function of neural pathways sustained by the neurotransmitters, like dopamine and serotonin. N-arylpiperazine moiety is important for CNS-activity, particularly for serotonergic and dopaminergic activity. In the scientific literature there are many examples of coumarin-piperazine derivatives, particularly with arylpiperazines linked to a coumarin system via an alkyl liner, which can modulate serotonin, dopamine and adrenergic receptors. Numerous studies have revealed that the inclusion of a piperazine moiety could occasionally provide unexpected improvements in the bioactivity of various biologically active compounds. The piperazine analogs have been shown to have a potent antimicrobial activity and they can also act as BACE-1 inhibitors. On the other hand, arylpiperazines linked to coumarin derivatives have been shown to have antiproliferative activity against leukemia, lung, colon, breast, and prostate tumors. Recently, it has been reported that coumarin-piperazine derivatives exhibit a Fneuroprotective effect by their antioxidant and anti-inflammatory activities and they also show activity as acetylcholinesterase inhibitors and antifilarial activity. In this work we provide a summary of the latest advances in coumarin-related chemistry relevant for biological activity.

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| S-EPMC9918894 | biostudies-literature

MXene-based novel nanocomposites doped SnO2 for boosting the performance of perovskite solar cells.

Project description:Since being first published in 2018, the use of two-dimensional MXene in solar cells has attracted significant interest. This study presents, for the first time, the synthesis of an efficient hybrid electrocatalyst in the form of a nanocomposite (MXene/CoS)-SnO2 designed to function as a high-performance electron transfer layer (ETL). The study can be divided into three distinct parts. The first part involves the synthesis of single-layer Ti3C2Tx MXene nanosheets, followed by the preparation of a CoS solution. Subsequently, in the second part, the fabrication of MXene/CoS heterostructure nanocomposites is carried out, and a comprehensive characterization is conducted to evaluate the physical, structural, and optical properties. In the third part, the attention is on the crucial characterizations of the novel nanocomposite-electron transport layer (ETL) solution, significantly contributing to the evolution of perovskite solar cells. Upon optimising the composition, an exceptional power conversion efficiency of more than 17.69% is attained from 13.81% of the control devices with fill factor (FF), short-circuit current density (Jsc), and open-circuit voltage (Voc) were 66.51%, 20.74 mA/cm2, and 1.282 V. Therefore, this PCE is 21.93% higher than the control device. The groundbreaking MXene/CoS (2 mg mL-1) strategy reported in this research represents a promising and innovative avenue for the realization of highly efficient perovskite solar cells.

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Novel chloroquinoline derivatives incorporating biologically active benzenesulfonamide moiety: synthesis, cytotoxic activity and molecular docking.

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| S-EPMC5080591 | biostudies-literature

Efficient Day-and-Night NO2 Abatement by Polyaniline/TiO2 Nanocomposites.

Project description:Finding innovative and highly performing approaches for NOx degradation represents a key challenge to enhance the air quality of our environment. In this study, the high efficiency of PANI/TiO2 nanostructures in the NO2 abatement both in the dark and under light irradiation is demonstrated for the first time. Heterostructures were synthesized by a "green" method and their composition, structure, morphology and oxidation state were investigated by a combination of characterization techniques. The results show that the unique PANI structure promotes two mechanisms for the NO2 abatement in the dark (adsorption on the polymeric chains and chemical reduction to NO), whereas the photocatalytic behavior prevails under light irradiation, leading to the complete NOx degradation. The best-performing materials were subjected to recycling tests, thereby showing high stability without any significant activity loss. Overall, the presented material can represent an innovative and efficient night-and-day solution for NOx abatement.

| S-EPMC9920043 | biostudies-literature