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Novel biologically active polyurea derivatives and its TiO₂-doped nanocomposites.

ABSTRACT: A new series of polyurea derivatives and its nanocomposites were synthesised by the solution polycondensation method through the interaction between 4(2-aminothiazol-4-ylbenzylidene)-4-(tert-butyl) cyclohexanone and diisocyanate compound in pyridine. The PU_1-3 structure was conﬁrmed using Fourier transform-infrared (FTIR) spectroscopy and characterised by solubility, viscometry, gel permeation chromatography (GPC), and X-ray diffraction (XRD) analysis. In addition, PU_1-3 was evaluated by TGA. Polyurea-TiO₂nanocomposites were synthesised using the same technique as that of PU_1-3 by adding TiO₂ as a nanofiller. The thermal properties of PU₂TiO₂a-d were evaluated by TGA. Moreover, the morphological properties of a selected sample were examined by SEM and TEM. In addition, PU_1-3 and PU₂TiO₂a-d were examined for antimicrobial activity against certain bacteria and fungi. The PU_1-3 showed antibacterial activity against some of the tested bacteria and fungi, as did PU₂TiO₂a-d, which increased with the increase in TiO₂ content. Furthermore, molecular docking studies were displayed against all PU_1-3 derivatives against two types of proteins. The results show that the increase in the strength of π-H interactions and H-donors contributed to improved binding of PU2 compared to PU1 andPU_3. The docking of 1KZN against the tested polymers suggests an increase in the docking score of PU_2, then PU₁, and PU₃, which is in agreement with the antibacterial study.

SUBMITTER: Hussein MA

PROVIDER: S-EPMC7448906 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Phase segregation and miscibility of TiOx nanocomposites in Gd-doped ceria solid electrolyte material.

Project description:Electro-chemo-mechanical (ECM) coupling refers to mechanical deformation due to electrochemically driven compositional change in a solid. An ECM actuator producing micrometre-size displacements and long-term stability at room temperature was recently reported, comprising a 20 mol% Gd-doped ceria (20GDC), a solid electrolyte membrane, placed between two working bodies made of TiOx/20GDC (Ti-GDC) nanocomposites with Ti concentration of 38 mol%. The volumetric changes originating from oxidation or reduction in the local TiOx units are hypothesized to be the origin of mechanical deformation in the ECM actuator. Studying the Ti concentration-dependent structural changes in the Ti-GDC nanocomposites is therefore required for (i) understanding the mechanism of dimensional changes in the ECM actuator and (ii) maximizing the ECM response. Here, the systematic investigation of the local structure of the Ti and Ce ions in Ti-GDC over a broad range of Ti concentrations using synchrotron X-ray absorption spectroscopy and X-ray diffraction is reported. The main finding is that, depending on the Ti concentration, Ti atoms either form a cerium titanate or segregate into a TiO2 anatase-like phase. The transition region between these two regimes with Ti(IV) concentration between 19% and 57% contained strongly disordered TiOx units dispersed in 20GDC containing Ce(III) and Ce(IV) and hence rich with oxygen vacancies. As a result, this transition region is proposed to be the most advantageous for developing ECM-active materials.

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Enhanced active oxidative species generation over Fe-doped defective TiO2 nanosheets for boosted photodegradation.

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