Association of blood pressure with cognitive function at midlife: a Mendelian randomization study.

ABSTRACT:

Background

Whether high blood pressure has a causal effect on cognitive function as early as middle age is unclear. We investigated whether high blood pressure (BP) causally impairs cognitive function at midlife using Mendelian Randomization (MR).

Methods

We applied a two-sample MR approach to investigate the causal relationship between BP and midlife cognitive performance measured by the Digit Symbol Substitution Test (DSST), Rey Auditory Verbal Learning Test (RAVLT), and Stroop Interference test. We used a total of 109 genetic polymorphisms with established associations with BP as instrumental variables and estimated gene-cognitive function association in 1369 middle-aged adults (Mean age (SD): 50.8 (3.3), 54.0% women) from the CARDIA study.

Results

A 10 mmHg increm

SUBMITTER: Sun D 

PROVIDER: S-EPMC7448985 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature